By Betty Martini
Mission-Possible-USA@altavista.net
August 5, 1999
An Aug 3 news release said research
is to be carried out on whether there are possible links between aspartame
and brain cancer. This is to be headed by neurochemist Dr. Peter Nunn of
Kings College in London. Monsanto (NutraSweet) says: "It is physiologically
impossible for aspartame to cause brain tumors because it never enters
the bloodstream and thus cannot travel to essential organs, including the
brain."
Aspartame is a molecule composed
of three components, aspartic acid, methanol and phenylalanine. H. J. Roberts,
M.D., says in Aspartame (NutraSweet) Is It Safe?
Page 30: "After ingestion there
is a rapid breakdown and absorption of aspartame within the upper gastrointestinal
tract. This results in a prompt rise of the two amino acids in the bloodstream."
Page 32: "Influence of Method
of Administration" Both phenylalanine and aspartame concentrations in the
blood plasma are significantly higher when aspartame is given as a solution
rather than in capsule form."
Aspartame, Physiology and Biochemistry,
Marcel Dekker, Inc., New York, L.D. Stegink and L. J. Filer, Jr., l984
(Pro industry, Significantly Corporate Sponsored!! ) Searle was original
manufacturer, bought by Monsanto in l985
Page 161: TISSUE DISTRIBUTION
OF ORALLY ADMINISTERED ISOTOPICALLY LABELED ASPARTAME IN THE RAT Yoshimasa
Matsuzawa and Yuichi O'Hara, Life Science Laboratory, Central Research
Laboratories, Ajinomoto Company, Inc. Yokohama, Japan
Page 162: RESULTS: Phenylalanine
Moiety: "The pattern of distribution of (U-14CPhe) aspartame following
its oral administration was very similar to that of (U-14C) phenylalanine
after 0.5, 2.6 and 24 hr and 7 days. Thirty minutes after administration
of these compounds, very high levels of radioactivity were observed in
the lumen of the stomach and upper small bowel. Significant uptake of radioactivity
was observed in the pancreas, gastrointestinal mucosa, hair follicles,
salivary gland and liver. Radioactivity was observed in the kidney, adrenal
gland, bone marrow, spleen and eye. Some radiolabel was localized to the
BRAIN, SPINAL CORD, (emphasis added) heart, thymus, lung and testes.
In real world demographic studies
that could be dated from July, l981 when aspartame became commercially
available, Dr. Roberts in DOES ASPARTAME CAUSE HUMAN BRAIN CANCER?, Journal
of Advancement in Medicine, Volume 4, Number 4, Winter1991, emphasized
the extraordinary rise of primary brain lymphoma in persons who were not
immunosuppressed within one or two years after the availability of aspartame
products. -- and for which no other reasonable cause could be identified.
Primary brain lymphoma had been a rare brain tumor prior to that time;
subsequently there was a striking rise of other more common primary brain
tumors within several years after the availability of aspartame in soft
drinks and other products, beginning July, l983. These data on brain cancer
statistics were regarded by the American Cancer Society statisticians as
significant, and for which no other cause was apparent.
Dr.Roberts report was a milestone
publication, presented 15 years after the previous demonstration of high
incidence of brain tumors in rats given aspartame. Indeed, these experimental
studies were the reason that FDA scientists, consultants for the GAO, and
a Public Board of Inquiry had urged the FDA Commissioner NOT TO APPROVE
aspartame for human use. Unfortunately, a new FDA Commissioner ignored
these warnings. In subsequent letters and books by Dr.Roberts, including
a communication published in Lancet, Vol. 349, Feb 1, l997, Roberts reemphasized
the matter, and urged the FDA to declare aspartame products an imminent
public health threat for their potential carcinogenic, neurologic,psychiatric,
metabolic and fetotoxic potential based on a clinical database now exceeding
1300 aspartame reactors.
As further refutation of assertions
by the manufacturer, and the FDA that there are no evidences for severe
neurotoxicity, Dr.Roberts and others have listed and reviewed many reports
to the contrary -- with emphasis on corporate - neutral studies involving
"real world" products subjected to heat and storage. Even corporate- sponsored
studies affirmed the matter. For example, one of 15pivotal studies submitted
to the FDA for approval of aspartame was a "52 Week Oral Toxicity Infant
Monkey Study (SC-18862). This study orally dosed aspartame to seven infant
Rhesus monkeys in work conducted at the University of Wisconsin Medical
Center at Madison. Reported in l972. The study reported "All animals in
the medium and high dosage groups exhibited seizure activity. Seizures
were observed for the first time following 218 days of treatment.
The seizures were of the grand
mal type.. One monkey, m38 of the high dose group, died after 300 days
of treatment. The cause of death was not determined .." The study correlates
brain seizures with high amounts of phenylalanine ingested by the monkeys.
The study determined: "following the end of the experiment, medium and
high dose monkeys were kept under observation for three months. No further
convulsions were detected during this period." In other words, once the
aspartame was withdrawn from the monkey's diets, the brain seizures ceased.
Monsanto spokesperson Dr. Robert Moser has said that aspartame does not
enter the blood stream. The data revealed by this "pivotal" study submitted
to FDA renders false Moser's assertion that Aspartame does not enter the
blood stream. Elevated levels of phenylalanine in the blood of monkeys
fed medium and high levels of Aspartame prove that the compound is absorbed
into the blood stream. The brain seizures followed. How could FDA claim
a "pivotal " study in which all of the medium and high dose monkeys suffer
brain seizures, confirm Aspartame's safety for humans?
Neurosurgeon Russell Blaylock,
M.D. in Excitotoxins: The Taste That Kills explains that for every
molecule of aspartame metabolized, a molecule of methanol was released
into the blood stream. An EPA assessment of methanol states that methanol
"is considered a cumulative poison due to the low rate of excretion once
it is absorbed" The absorbed methanol is then slowly converted to formaldehyde
by alcohol dehydrogenase in the liver (DHHS 1993a, Liesivuori 1991). The
formaldehyde is then converted to formic acid by aldehyde dehydrogenase
in the liver, by formaldehyde dehydrogenase in the blood or through the
tetrahydrofolic acid dependent, one-carbon pool (Liesivuori 1991). Methanol
thus breaks down into formaldehyde and formic acid in the body. Journal
of the Diabetic Assoc. of India, A Health Alert, Emerging Facts About
Aspartame, Vol. No. 35, No. 4: l995, J. Barua, A. Bal
During Congressional Hearings
on aspartame there was voluntary submission of Trade Secret Information,
Document 31. This had to do with Food and Drug Sweetener Strategy on getting
aspartame approved and says in the last paragraph: "With the spoon-for-spoon,
we have no way of estimating maximum likely abuse and hence need to utilize
data based on almost complete conversion to DKP. If we include this use
in the original FAP, we stand a good chance of ending up with nothing in
the short run and nothing in the long run whereas the other approach would
give us something in the short run and quite likely as much as we would
ever get in the long run."
..
DKP is diketopiperazine and has
been implicated in the occurrence of brain tumors. Dr. John Olney, noticed
that DKP, when nitrosated in the gut, produced a compound which was similar
to N-nitrosourea, a powerful brain tumor causing chemical.
What is so serious about this
situation is that Searle knew before they marketed aspartame that the phenylalanine
would break down to DKP, and they didn't think they could get it approved
if the FDA found out. Indeed, rats developed brain tumors in original studies.
An FDA toxicologist who tried to stop the approval of aspartame, the late
Dr. Adrian Gross, told Congress that because aspartame was capable of producing
brain tumors and brain cancer, FDA should not have been able to set an
allowable daily intake of the substance at any level. He said at least
one of Searle's studies "has established beyond any reasonable doubt that
aspartame is capable of inducing brain tumors in experimental animals and
that this predisposition of it is extremely of high significance..In view
of these indications that the cancer causing potential of aspartame is
a matter that had been established way beyond any reasonable doubt, one
can ask:
What is the reason for the apparent
refusal by the FDA to invoke for this food additive the so-called Delaney
Amendment to the Food, Drug and Cosmetic Act?" The Delaney Amendment makes
it illegal to allow any residues of cancer causing chemicals in foods.
The concluding testimony of Dr. Gross will never be forgotten. He asked:
"Given the cancer causing potential of aspartame, how would the FDA justify
its position that it views a certain amount of aspartame as constituting
an allowable daily intake or 'safe" level of it? Is that position in effect
not equivalent to setting a 'tolerance' for this food additive and thus
a violation of that law? And IF THE FDA ITSELF ELECTS TO VIOLATE THE LAW,
WHO IS LEFT TO PROTECT THE HEALTH OF THE PUBLIC?" (Emphasis added). Congressional
Record SID835:131 (August 1, l985)
In Nov l996 John W. Olney, M.D,
reported that brain tumor rates had risen for 17 years with a sudden 10%
increase three years after aspartame was introduced. Olney linked aspartame's
mutagenicity to the function of aspartate as an excitotoxic neurotransmitter.
Dr. Olney appeared on 60 Minutes and with him Dr. Ralph Walton who declared
that only NutraSweet funded studies showed safety and that 83 of 90 independent
studies show it harmful. This year world famous toxicologist, George Schwartz,
M.D., in writing to Monsanto said: "By ignoring the scientific studies
which disagree with your position, you are doing a great disservice to
consumers. Further, you may have created base for litigation against your
company by denying the existing science." (letter on www.dorway.com)
Dr. H. J. Roberts has now declared
Aspartame Disease to be a world epidemic and is in the process of publishing
a 700 page medical text on the world plague.
Suggested documents to review:
FDA audit, Bressler Report CDC
Investigation Protest of National Soft Drink Association
Letters from Dr. Adrian Gross
to Senator Metzenbaum
Affidavit from N. Vera,translator,
that studies were done in South America on humans that showed aspartame
triggered brain tumors and seizures, and were never published by
Searle.
These documents on http://www.dorway.com
Betty Martini, Founder
Mission Possible International
9270 River Club Parkway
Duluth, Georgia 30097
770 242-2599
Mission Possible Intl is a worldwide
volunteer force alerting consumers aspartame is a neurotoxin. Two
support groups have been set up on the Internet for the victims of
Aspartame Disease.
The important thing is in intact
human beings who are exposed to this on a sustained level, not just
with just a couple of doses or so , its cumulative. (Said by H. J. Roberts,
M.D.)
*******************************
1. Take the 60-day No Aspartame
Test and send us your case history.
Mission Possible International
9270 River Club Parkway
Duluth, GA 30097 USA
770-242-2599
2. Tell your doctor and all of
your friends!
3. Return Asparcidal food to the
store.
(anything with Monsanto's NutraSweet/Equal/Spoonful/Benevia/NatraTaste)
VISIT http://www.dorway.com
Get links to over 200 sites on aspartame
VISIT http://www.holisticmed.com/aspartame/
FAQs & Cases
VISIT
http://www.notmilk.com Exposing Bovine Growth Hormone
VISIT http://www.icanect.net/sunpress/
Books on aspartame by Dr.Roberts
Disability and Death
are not acceptable costs of business!
Free Newsletter |
---|
|
All information posted on this web site is the opinion of the author and is provided for educational purposes only. It is not to be construed as medical advice. Only a licensed medical doctor can legally offer medical advice in the United States. Consult the healer of your choice for medical care and advice. |