By Dr. Manners
Posted June 26, 2004
What Is The Laetrile Therapy?
Metabolism is the total function of our body. In order for
our body to function properly, all its attributes (physical, mental, and
spiritual) must work in harmony. Total care is the goal of the Metabolic
Therapy, has several elements that are utilized in order to provide our
human organism the best environment to combat the disease and regain health.
The Metabolic Therapy, our primary nontoxic cancer treatment, is based on
the use of laetrile, digestive enzymes, immuno-stimulants, mega-doses of
vitamins and minerals, spiritual, nutritional, and psychological support.
The metabolic Therapy is not complete without its chief anti-tumor agent.
Laetrile (B-17) is a natural chemotherapeutic agent found
in over 1,200 plants, particularly in the seeds of common fruits such as
apricots, peaches, plums, and apples.
It is a diglucocide with a cyanide radical that is highly"bio-accessible".
This means that it penetrates through the cellular membrane reaching high
intracellular concentrations easily. The cyanide radical is what preoccupies
most scientists, but it has been proved that Laetrile (B-17) is completely
nontoxic. Our own experience with hundreds of patients give us complete
confidence that there is no danger. The normal cells in our organism contain
an enzyme called Rodhenase which "neutralizes" the laetrile.
This enzyme does not allow the laetrile to release the cyanide.
In this way, laetrile only serves as a glucose to healthy cells providing
energy. Malignant cells do not contain this enzyme. In the absence of Rodhenase,
the laetrile is activated liberating the cyanide radical inside the malignant
cell causing its destruction. This is the way God creates things:
only cancerous cells are destroyed but normal ones are not affected.
As the laetrile attacks unhealthy cells, it transforms into
silicate which is much like aspirin. It contributes greatly to pain control.
Though it has limitations in certain cancers, it is extremely effective
in the most common tumors such as Carcinoma of the Lung, Breast, Prostate,
Colon, and Lymphomas .
A highly publicized clinical trial conducted by the National
Cancer Institute (NCI) in 1981, tried unsuccessfully to prove that Laetrile
was ineffective and toxic. Today, Laetrile occupies a position on the "front
lines" of Alternative Cancer Therapies. We have found Laetrile to be
effective on people that have active cancer; but that is not its only function.
For prevention of cancer and the maintenance of remission there is nothing
as effective as Laetrile. Its non-toxicity permits its use indefinitely
in the prevention of relapses and the prevention of metastases. Surgery,
Radiation, and Chemotherapy can only be administered for a limited time,
afterwards patient are left without any protection.
There is no doubt that the struggle against cancer is the
greatest challenge that medical science has ever faced. There is no other
disease to which more money is devoted, or to which scientists dedicate
more hours of study. The magnitude of the cancer problem may be demonstrated
by a few statistics. One of three Americans will develop Cancer during their
lifetime, and one out of four will die from it. This year, over 989,200
people will die from cancer in the USA .
Cancer is increasing in all age categories. Lifestyle, nutrition,
food additives, pesticides, ultraviolet radiation and a variety of other
environmental factors are directly implicated. With certain exceptions,
cancer appears to be a man-made disease and is therefore a preventable disease.
It is now apparent that cancer may be caused by an almost limitless variety
of physical, chemical and biological agents. Although it is true that surgery
an radiotherapy are capable of curing some patients with localized tumors
and that chemotherapy has achieved cures in some malignant tumors, the general
mortality rate from cancer is increasing. Many patients cannot be exposed
to chemotherapy, surgery or radiotherapy because of the undesirable effects
over their poor physical condition resulting from cancer.
All this justifies, and even makes imperative, the search
for new substances with anti-tumoral effects and ideally with little or
no toxicity in therapeutic dosages. In the last 15 years, several herbs
and hormonal substances have been discovered with such characteristics.
Therefore, many patients who formerly could not be benefited or alleviated
medicinally may not be exposed to useful anti-neoplastic treatments. Nature
provides an arsenal to destroy tumors or at least to neutralize their growth.
The leading natural therapy is Amygdalin, better known as
Laetrile, a product made with the purest amygdalin, obtained from apricot
kernels (bitter almonds), through an exclusive extraction process.
What Is The Nature Of Cancer?
In order to intelligently discuss any form of therapy, it
is essential to know something about the nature of the disease. Cancer has
been defined as a cellular tumor, the natural course of which is fatal.
Another term for cancer is a malignant neoplasm . Neoplasm refers to a progressive
uncontrolled new growth of tissue.
The term tumor may be correctly applied to any neoplasm, benign
or malignant. A benign tumor is one that lacks the ability to invade other
tissues and does not spread or metastasize , and for the most part can be
surgically removed. A malignant tumor or cancer is characterized by it's
ability to invade tissue, metastasize, the cells are less differentiated
(a process known as anaplasia , in which the tumor cells do not resemble
those of the parent tissue), and ultimately results in the death of the
victim. The term metastasis refers to the transfer or spread of the cancer
from one organ or part to another not directly connected with it. Thus,
tumor cells may originate in one part of the body ( primary tumor ) and
suddenly appear in some other organ or distant part of the body ( secondary
Metastases are a significant factor in bringing about the
death of the patient. There are over 100 different clinical types of cancers
which are frequently divided into the two broad categories of carcinomas
and sarcomas . Carcinomas are malignant new growths of epithelial cells
and may involve the breasts, digestive tract, uterus, skin, etc. Sarcomas
are malignant new growths of connective tissue and involve such organs as
bone, muscle, nerves, lymph glands, etc. Hodgkin's disease and melanomas
are a type of sarcoma. In general, tumors are classified according to the
cell type involved, and occasionally they are of the mixed type containing
both epithelial and connective elements. The leukemias are another type
of malignancy that involves a progressive proliferation of the blood forming
organs of the body. Leukemia is sometimes referred to as cancer of the blood.
The typing and grading of malignant tumors becomes very complicated
and goes far beyond the intent of this publication. In order to explain
some of the more basic elements of carcinogenesis, it is necessary to deal
with some of the fundamental of cell structure and function. The major subdivisions
of a cell include the nucleus and the surrounding cytoplasm . The nucleus
is the primary control center of the cell. Chromosomes are a structure in
the nucleus comprised of a linear thread of a nucleic acid known as deoxyribonucleic
acid (DNA) . Chromosomes appear as elongated threadlike bodies in the nucleus
and are clearly visible only when the cell is undergoing division. The chromosomes
are comprised of nucleic acid and protein. The nucleic acid DNA transmits
genetic information. The chromosomes also bear the basic units of heredity
called genes .
The genes determine the characteristics of the cells, and
act as control units in the metabolic activities of the cell. Genes therefore
serve as code units which determine most of the enzymatic and other biochemical
activities within the cell. It is through the genes that this basic metabolic
data is passed on from one generation of cells to the next. The cytoplasm
surrounding the nucleus of the cell contains a complex network of membranes
known as the endoplasmic reticulum . This reticulum is lined on its outer
surface by small particles called ribosomes . The ribosomes contain large
concentrations of a nucleic acid known as ribonucleic acid (RNA).
These ribosomes are directly concerned with protein synthesis.
RNA also occurs in the nucleus of the cell. It is now known that RNA is
synthesized in the nucleus of the cell and migrates to the cytoplasm. The
DNA acts as a template or pattern for the synthesis of RNA, which in turn
acts as a biochemical messenger between the DNA of the nucleus and the metabolic
machinery of the cytoplasm. Thus, RNA appears to exert a controlling influence
over the entire metabolic activities of the cell. Any alteration in the
DNA mechanism is going to affect the RNA messenger and thereby alter the
metabolic changes in the cell. In case of cancer, the regulatory mechanism
that governs cell division is obviously affected and the cells begin to
rapidly proliferate and gradually lose their differentiation.
There are numerous theories that have been proposed as to
the cause of cancer. It is now apparent that cancer may be caused by an
almost limitless variety of physical, chemical and biological agents. However,
it is becoming increasingly apparent that regardless of the precipitating
factor, somewhere along the progression of biochemical events, the basic
DNA-RNA mechanism is involved. If this vital genetic machinery is damaged,
cancer may be the end result. It would appear that if the cause of cancer
is due to an alteration of the normal metabolism of the cell, then the correction
of the problem would be by means of a Metabolic approach, which is basically
the subject of this web page.
Amygdalin ( Laetrile ) History and Actions
Amygdalin is a herbal constituent derived from the kernels
of various fruits of the Genus Prunus (synonym amygdalus) , which includes
the plum, prune, cherry, peach and apricot. It is among the most ancient
herbal products used against cancer. Apricot kernels have been in medical
use since the days of Pen T'sao (great Chinese Herbalist), in the year 2800
B.C., in ancient China. Also, the great Persian master of pharmacy, medicine
and natural sciences, Avicenna (980-1037) recommended the use of apricot
bitter almond oil in the treatment of tumors of the spleen, uterus, stomach
and liver. Amygdalin is one of the first and best known cyanogenic glycosides.
The systematized study of amygdalin did not really begin until the first
half of the past century when crystalline amygdalin was isolated in 1830
by two French chemists, Robiquet and Boutron. Now known as Prunus Amygdalus,
of the rose family Rosaceae, amygdalin is hence appropriately named after
the scientific name of the bitter almond. The chemical structure of amygdalin
is well established as laevo-D-mandelonitrile-B-D-glucoside-6-B-D-glucoside;
essentially, it is a diglucoside with a cyanide radical. Laetrile is a decomposition
product resulting from the hydrolysis of amygdalin. Neither amygdalin nor
laetrile contain free cyanide. Laetrile formula is laevo-D-mandelonitrile-B-glucoronide.
The term laetrile was first proposed by Ernest T. Krebs, Jr. in 1949.
The word is derived from the contraction of the chemical term
LAE vo-mandeloni TRILE . Krebs also designated laetrile as vitamin B17 .
Krebs contended that amygdalin is essential to human health. The Amygdalin
Therapy The amygdalin (laetrile) therapy utilizes the cyanogenic glycoside
amygdalin, or one of it's byproducts, together with a broad-based nutritional
program Metabolic Therapy for the control of cancer. Krebs, Jr. and his
research group found that amygdalin has it's powerful cancer killer capabilities
because it contains cyanide that destroys cancer cells. Not all cyanide
compounds are poisonous, humans constantly eat produce with cyanide, about
1,200 kinds of foods have it. Detoxification of cyanide can take place in
all tissues of the body, but principally in the liver. The dosage levels
and toxicity of amygdalin (laetrile) in laboratory animals and humans is
well established and documented. No evidence of acute or accumulative toxicity
was observed in any animals giving doses in excess of 100 times the maximum
intravenous dose usually given in humans.
These findings coincide with that mentioned by Otto Jacobsen
in 1887, Davidson in 1944 and Dr. Dean Burk ( National Cancer Institute)
in 1968: "Amygdalin is impressively nontoxic from the pharmacological
point of view", and "non-hydrolyzed amygdalin is less toxic than
glucose". The oral toxicity of amygdalin was found to be 39 to 44 times
greater than the intramuscular route, and more toxic than intravenous route
(parentenal route). Amygdalin is less tolerable by oral administration because
of the hydrolysis of amygdalin by the gastric juices. On the other hand,
amygdalin, in dosages of 20-40/mg/kg orally (for a 200 lb human this would
translate to 16 - 500mg laetrile/B17 tablets, daily), used in humans, is
10 to 20 times less than the minimum toxic dosage in dogs. The biological
half life of amygdalin is only 80 minutes. Over 80% of the amygdalin administered
is excreted from the body in 4 hours. The usual metabolic approach to amygdalin
(laetrile) therapy is to provide the patient with adequate nutritional support,
with relatively nontoxic high doses of vitamins and minerals, and other
active natural substances.
Amygdalin (laetrile) has been administered in dosages of up to 70 grams
(70,000 miligrams-mg) per day in adult humans by combined oral and parentenal
routes without adverse effects.
Amygdalin's Action Mechanisms (Krebs Hypothesis)
The most widespread theory ("cyanide theory") on
the action of amygdalin was propounded by Ernest Krebs, Jr. in the seventies.
Krebs hypothesis: The resulting end products of the hydrolysis of amygdalin
are the hydrocyanic acid (HCN) and benzaldehyde. In order to produce these
products B-glucuronidase is required. It has been demonstrated that this
enzyme is present in cancerous tissue, about 1,000 to 3,600 times higher
than in normal tissue. Rhodanase is an enzyme found in the liver cell and
is known to be concerned with the conversion of toxic hydrocyanic acid to
thiocyanate, a harmless substance. Rhodanase is part of the normal detoxification
process of the body. However, it was found that normal cells contain a relatively
high concentration of rhodanase and low concentration of B-gluco-ronidase,
whereas cancerous cells are high in available B-glucoronidase and low in
Thus, the normal cellular protective mechanism is decreased
in tumor cells and they become more sensitive to the effects of the cyanide
ion. The HCN would tend to depress the enzyme functions of the cancer cell
and thereby destroy it. Since normal cells contain large quantities of rhodanase
and relatively low quantities of available B-glucoronidase, the available
rhodanase would detoxify the cyanide ion (CN-), forming the non-toxic thiocyanate.
Then according to Ernest Krebs amygdalin's toxic effect is against the cancerous
cell and not the host.
The Effectiveness Of Amygdalin (laetrile) In Cancer
Ever since the days of Louis Pasteur (1822-1895) and Paul
Ehrlich (1854-1915), cancer victims have hoped for the "wonder vaccine"
or the "magic bullet". Amygdalin (laetrile) does not come under
the heading of either of these dramatic therapies. There are a number of
factors that enter into the cancer treatment complex. The type of cancer
involved is an important factor. Some types of cancer tend to be more sensitive
to treatment than other. Amygdalin (laetrile) is not equally effective in
all types of cancers. Rubin (1977) found in their clinical investigations
in Israel that Amygdalin (laetrile) was most effective against Adenocarcinoma
and Hodgkin's disease, somewhat less effective in certain other of the Sarcomas
and Melanomas , and relatively poor results were achieved with the Leukemia.
Similar results have been obtained by other clinicians in the United States
and elsewhere. The best results with Amygdalin (laetrile) therapy have been
achieved with Lung, Prostate, Breast, Lymphomas, Liver and Brain cancer.
The chemical quality of the Amygdalin (laetrile) also has a bearing on the
clinical therapeutic results.
Only the laevo isomer of Amydalin (laetrile) has been found
to be therapeutically active. A high quality Amygdalin is now produced in
Mexico and some products are currently under investigation in the United
States and Germany . It is therefore of the utmost importance that quality
products be utilized. Failure to recognize this point can result in inadequate
dosage levels and false negative therapeutic results (Krible, 1912; Levi,
et al, 1965; Rubin, 1978). Other factors relating directly to the administration
of Amygdalin (laetrile) concern the dosage. In the past, most physicians
have tended toward administering too low a dosage. Therefore the frequency
of administration, the route of administration, and the dosage are of the
utmost importance if adequate blood levels are to be maintained. In the
past, most errors of administration have been made on the side of too little,
rather than too much. However, it should be kept in mind that the most effective
routes are by parenteral injection (I.M or I.V.) and the physician should
not attempt to achieve the necessary dosage levels by the oral route. Rubin
(1978) reports administering 70gr. per day to each patient with no ill effects.
Another aspect that will have a bearing on the recovery of a patient depends
upon the degree of tissue damage caused by excessive radiation and toxicity
resulting from chemotherapy.
It is presently estimated in the United States, Mexico, and
elsewhere, that about 90% or more of the patients begin using Amygdalin
(laetrile) only after all other types of cancer therapies have failed. Most
metabolic physicians are of the opinion that if the patient were to begin
Metabolic Therapy earlier in the course of the disease, it would improve
the patient's chances of Cancer Control. The adequacy of liver functions
is of the utmost importance in cancer therapy. The liver has varied, intricate
and extremely complex metabolic functions. Among other things the liver
is concerned with fat, carbohydrate and protein metabolism.
The liver has a propensity for storing vitamins, especially
A, D and B 12 , and Iron in the form of ferritin. The liver forms a large
proportion of the blood constituents: Fibrinogen, Prothrombin, Accelerator
Globulin, Factor VII, and other coagulation factors. The liver is involved
in vitamin K metabolism. The liver is concerned with the vascular storage
and filtration of blood, with about 1000ml of blood flowing from the portal
vein through the liver sinusoids each minute, and an additional 400ml flows
into the sinusoid from the hepatic artery. Thus when the liver or kidneys
are damaged due to a primary or metastatic malignancy, it may adversely
affect the entire metabolism of the body.
The studies conducted thus far on Amygdalin (laetrile) indicate
that there is no damage to the liver or kidney function. Much of the effort
of metabolic therapy is dedicated toward sustaining adequate liver and kidney
functions, and to attempt to minimize the detoxification load placed upon
them. It should be emphasized that Amygdalin (laetrile) therapy is most
effective when used in conjunction with a comprehensive METABOLIC approach.
Most physicians using this form of therapy provide adequate nutritional
support with the use of proper vitamin and mineral supplements. The patient
is placed on a complete vegetarian diet with a reduction of proteins, fats,
refined sugars, and processed foods. All tobacco, alcohol, caffeinated drinks,
and most toxic medications are eliminated. The patient is placed on a high
intake of select fruit juices, fresh fruits and vegetables. A program of
Detoxification is required. A minimum of 9gr of Amygdalin (laetrile) per
day is administered, largely by the parenteral route, but even higher levels
may be given if indicated. Patients that refuse to follow the general Metabolic
Program are discouraged from taking Amygdalin (laetrile) .
Alternative Forms Of Cancer Treatments
There are probably as many different forms of cancer therapy
as there are types of cancer. There are cancerous conditions which require
surgery, radiation, and/or chemotherapy. There are certain types of cancer,
and certain stages in the development of the cancer, that respond well to
one or more modalities. Significant success has been obtained in the treatment
of Hodgkin's disease, some leukemias, and certain other types of cancers.
The patient is advised to consult with a physician and seek the best medical
advice available. Most skin cancers can be readily treated with conventional
methods of therapy if instituted early enough. However, the most common
type of internal cancer is adenocarcinoma (involving the breast, intestinal
tract, lung, etc.). When an adenocarcinoma and certain of the sarcomas undergo
metastases, most conventional therapy is ineffective and the prognosis of
the patient is poor, using conventional therapies. The patient is then left
with the dilemma of Where do I go from here?
These cases should be encouraged to try Amygdalin (Laetrile)
Therapy . If the cancer victim is trying to decide how to proceed, whether
to stay with conventional therapy or the Life Without Cancer Amygdalin (laetrile)
therapy the following procedure is recommended: The patient should determine
from his physician the type of cancer with which he is afflicted and then
visit the Cancer Ward at any major medical center in the United States.
Most patients will find it very educational to visit a high-class conventional
Cancer Ward, subsidized by the National Cancer Institute and the American
Cancer Society , and check with the doctors, nurses and patients and see
for themselves just how many "terminal cancer victims" actually
survive the ordeal.
The fact that the wealthiest persons, most influential politicians,
brightest Hollywood stars, highly educated persons, and skilled orthodox
physicians are dying of metastatic malignancies should be suitable commentary
as to the efficacy of conventional therapy. The studies made in 1977, indicate
that persons that combine Amygdalin (laetrile) with conventional chemotherapy
are able to tolerate higher doses of toxic chemotherapeutic agents with
far less side effects. Interestingly enough, this synergism is characteristic
of adaptogenic agents.
What Of The Future?
Here is the forecast based on the evidence currently on hand:
a) Clinical trials on Amygdalin (laetrile) therapy using good
quality Amygdalin will continue to be conducted in the proper manner.
b) Amygdalin (laetrile) will be legalized in the United States
with or without the cooperation of the FDA at some point in the future.
c) The atrocities now being committed in the name of orthodox
medicine, the suppression of life-giving scientific data, the needless loss
of lives, mutilation of bodies, and excessive suffering, all for the financial
benefit of a ruthlessly powerful medical cartel which is flagrantly in violation
of the antitrust laws of this government, will not continue to be tolerated
by the American people.
Ultimately, these criminals and their political lackeys will
be brought to trial and they will find themselves responsive to the American
people. The following is one of the greatest rights ever given to a people:
"NO STATE SHALL MAKE OR ENFORCE ANY LAW WHICH SHALL ABRIDGE THE PRIVILEGES
OR IMMUNITIES OF CITIZENS OF THE UNITED STATES: NOR SHALL ANY STATE DEPRIVE
ANY PERSON OF LIFE, LIBERTY, OR PROPERTY, WITHOUT DUE PROCESS OF LAW, NOR
DENY TO ANY PERSON WITHIN ITS JURISDICTION THE EQUAL PROTECTION OF THE LAWS"
. (from the 14th amendment of the constitution of the United States of America.
All information posted on this web site is
the opinion of the author and is provided for educational purposes only.
It is not to be construed as medical advice. Only a licensed medical doctor
can legally offer medical advice in the United States. Consult the healer
of your choice for medical care and advice.